Essentials: The Biology of Slowing & Reversing Aging
October 30, 2025 · 33 min · 19 chapters
Chapters
- 0:00David Sinclair
- 0:20Longevity, Anti-Aging, Aging as a Disease
- 2:27Causes of Aging; Epigenome & Genes
- 4:53CD & Scratches Analogy, DNA, Silencing & Expressing Genes
- 6:44Physical Appearance & Aging
- 7:36Childhood Development & Aging, Horvath Clock, Accelerate Aging
- 10:13Rates of Puberty & Aging, Growth Hormone
- 11:20Body Size & Longevity; Epigenetics
- 11:50Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose
- 15:14Tool: Skip a Meal
- 15:50Longer Fasts & Autophagy, “Deep Cleanse”; Fluids, Electrolytes
- 17:28Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors
- 21:37Breaking a Fast, Tools: Do Your Best; Transitions
- 24:13Sirtuins, NAD, NMN Supplementation
- 26:20Iron & Senescent Cells; Personalize Medicine
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